Y-The Last Man
This was the comic that convinced me I could move beyond super-heroes. While Fables started two months earlier, that had a built writer whose work I liked. This had to stand on its own.
The premise of Y: The Last Man is simple: what would happen if every man on the planet was simultaneously and instantly killed by a mysterious plague. Every man except one: Yorrick Brown. The 60 issue series follows Yorrick and his eventual band of travelers as they cross the globe trying to determine why Yorrick is the only man to have survived the plague.
And some gorgeous covers by J.G. Jones and Massimo Carnevale...