If I was going to use the stats of my collection, then the issue that best represents my taste in comics would have to be written by Brian Michael Bendis or John Byrne, with pencils by John Byrne, inks by Art Thibert or Joe Rubinstein and colored by Glynis Oliver Wein. It was published by Marvel Comics, probably in 2005 (even though I bought it in 2003), and although it stars Superman (A DC character!) it was probably an Avengers book (A Marvel title!).
That being said, the above book WAS co-published by Marvel and was colored by Glynis Wein, but that is about it.
I like this book for a lot of reasons. It came out when I was collecting both titles so it was neat for me to see the teams together. At that point, work between Marvel and DC was quite rare so this was more special. It also gave hope to those of us expecting to see the long promised Justice League of America/Avengers crossover (though it would take 20 years to see that one!!).
The two different universes were blended seamlessly. Characters seemed to have a knowledge of each other and shared some history....and they worked together (after a short, seemingly required fight).
And if you knew your comic book history, you had even more of a treat, as the story had some nice little nuggets embedded in it. And the villains.....
Gorgeous art, tight (nearly) self-contained story. Great characters and a cosmic scope.....a great book.